abnormal class switch recombination_Aicda<tm1Hon>/Aicda<tm1Hon>

http://metadb.riken.jp/0004816IC57BL6CBAAicdatm1HonAicdatm1HonAicdatm1Hon

abnormal class switch recombination_Aicda<tm1Hon>/Aicda<tm1Hon>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• activation-induced cytidine deaminase
  http://metadb.riken.jp/db/mgi_rdf/MGI:1342279

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Aicda<tm1Hon>/Aicda<tm1Hon>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Aicda<tm1Hon>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal class switch recombination
  http://purl.obolibrary.org/obo/MP_0004816

文献

http://purl.org/net/cito/citesAsAuthority

• Bernardo. Reina-San-Martin, et.al., H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation., The Journal of experimental medicine, 2003, 197
  http://rdf.ncbi.nlm.nih.gov/pubmed/12810694
• M. Muramatsu, et.al., Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme., Cell, 2000, 102
  http://rdf.ncbi.nlm.nih.gov/pubmed/11007474
• Kevin M. McBride, et.al., Regulation of class switch recombination and somatic mutation by AID phosphorylation., The Journal of experimental medicine, 2008, 205
  http://rdf.ncbi.nlm.nih.gov/pubmed/18838546