abnormal osteoclast morphology_Slc4a2<tm2Ges>/Slc4a2<tm2Ges>,Ctsk<tm1(cre)Ska>/Ctsk<+>

http://metadb.riken.jp/0004982IC57BL6NCrljCBAJNCrljSlc4a2tm2GesSlc4a2tm2GesCtsktm1creSkaCtskCtsktm1creSkaCtskSlc4a2tm2Ges

abnormal osteoclast morphology_Slc4a2<tm2Ges>/Slc4a2<tm2Ges>,Ctsk<tm1(cre)Ska>/Ctsk<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cathepsin K
  http://metadb.riken.jp/db/mgi_rdf/MGI:107823
• solute carrier family 4 (anion exchanger), member 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:109351

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Slc4a2<tm2Ges>/Slc4a2<tm2Ges>,Ctsk<tm1(cre)Ska>/Ctsk<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ctsk<tm1(cre)Ska>|Ctsk<+>|Slc4a2<tm2Ges>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6NCrlj * CBA/JNCrlj

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal osteoclast morphology
  http://purl.obolibrary.org/obo/MP_0004982

文献

http://purl.org/net/cito/citesAsAuthority

• Fabienne. Coury, et.al., SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts., Proceedings of the National Academy of Sciences of the United States of America, 2013, 110
  http://rdf.ncbi.nlm.nih.gov/pubmed/23341620