increased osteoclast cell number_Esr1<tm1.1Scma>/Esr1<tm1.1Scma>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0004984I129P2OlaHsd129S4SvJaeSorC57BL6Esr1tm11ScmaEsr1tm11ScmaLyz2tm1creIfoLyz2Lyz2tm1creIfoLyz2Esr1tm11Scma

increased osteoclast cell number_Esr1<tm1.1Scma>/Esr1<tm1.1Scma>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• estrogen receptor 1 (alpha)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1352467
• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Esr1<tm1.1Scma>/Esr1<tm1.1Scma>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lyz2<tm1(cre)Ifo>|Lyz2<+>|Esr1<tm1.1Scma>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased osteoclast cell number
  http://purl.obolibrary.org/obo/MP_0004984

文献

http://purl.org/net/cito/citesAsAuthority

• Marta. Martin-Millan, et.al., The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone., Molecular endocrinology (Baltimore, Md.), 2010, 24
  http://rdf.ncbi.nlm.nih.gov/pubmed/20053716