decreased osteoclast cell number_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

http://metadb.riken.jp/0004985I129S1Sv129X1SvJC57BL6FVBNSJLGtROSA26Sortm1rtTAEGFPNagyGtROSA26SorTgCol2a1cre1Bhr0TgtetOVegfa90Ala0GtROSA26SorTgtetOVegfa90AlaTgCol2a1cre1BhrGtROSA26Sortm1rtTAEGFPNagy

decreased osteoclast cell number_Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 90, Ann L Akeson
  http://metadb.riken.jp/db/mgi_rdf/MGI:3586337
• transgene insertion 1, Richard R Behringer
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176069
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>/Gt(ROSA)26Sor<+>,Tg(Col2a1-cre)1Bhr/0,Tg(tetO-Vegfa)90Ala/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Tg(tetO-Vegfa)90Ala|Tg(Col2a1-cre)1Bhr|Gt(ROSA)26Sor<tm1(rtTA,EGFP)Nagy>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased osteoclast cell number
  http://purl.obolibrary.org/obo/MP_0004985

文献

http://purl.org/net/cito/citesAsAuthority

• Christa. Maes, et.al., Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones., The EMBO journal, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20010698