decreased osteoclast cell number_Nfatc1<tm3Glm>/Nfatc1<tm3Glm>,Sh3bp2<tm1Bjro>/Sh3bp2<tm1Bjro>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0004985I129S4SvJaeC57BL6CBANfatc1tm3GlmNfatc1tm3GlmSh3bp2tm1BjroSh3bp2tm1BjroTgMx1cre1Cgn0Nfatc1tm3GlmTgMx1cre1CgnSh3bp2tm1Bjro

decreased osteoclast cell number_Nfatc1<tm3Glm>/Nfatc1<tm3Glm>,Sh3bp2<tm1Bjro>/Sh3bp2<tm1Bjro>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:102469
• SH3-domain binding protein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346349

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nfatc1<tm3Glm>/Nfatc1<tm3Glm>,Sh3bp2<tm1Bjro>/Sh3bp2<tm1Bjro>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nfatc1<tm3Glm>|Tg(Mx1-cre)1Cgn|Sh3bp2<tm1Bjro>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased osteoclast cell number
  http://purl.obolibrary.org/obo/MP_0004985

文献

http://purl.org/net/cito/citesAsAuthority

• Antonios O. Aliprantis, et.al., NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism., The Journal of clinical investigation, 2008, 118
  http://rdf.ncbi.nlm.nih.gov/pubmed/18846253