increased bone resorption_Ctsk<tm1(cre)Ska>/Ctsk<+>,Esr1<tm1Mma>/Esr1<tm1Mma>

http://metadb.riken.jp/0004992I129S2SvPasC57BL6SJLCtsktm1creSkaCtskEsr1tm1MmaEsr1tm1MmaEsr1tm1MmaCtskCtsktm1creSka

increased bone resorption_Ctsk<tm1(cre)Ska>/Ctsk<+>,Esr1<tm1Mma>/Esr1<tm1Mma>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cathepsin K
  http://metadb.riken.jp/db/mgi_rdf/MGI:107823
• estrogen receptor 1 (alpha)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1352467

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctsk<tm1(cre)Ska>/Ctsk<+>,Esr1<tm1Mma>/Esr1<tm1Mma>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Esr1<tm1Mma>|Ctsk<+>|Ctsk<tm1(cre)Ska>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased bone resorption
  http://purl.obolibrary.org/obo/MP_0004992

文献

http://purl.org/net/cito/citesAsAuthority

• Takashi. Nakamura, et.al., Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts., Cell, 2007, 130
  http://rdf.ncbi.nlm.nih.gov/pubmed/17803905