decreased B cell number_Tlr4<Lps-d>/Tlr4<Lps-d>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

http://metadb.riken.jp/0005017I129P2OlaHsdC3HHeJC57BL6Tlr4LpsdTlr4LpsdTgIghelMD44Ccg0TgKLK4mHEL6Ccg0TgIghelMD44CcgTgKLK4mHEL6CcgTlr4Lpsd

decreased B cell number_Tlr4<Lps-d>/Tlr4<Lps-d>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 4, Christopher C Goodnow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053738
• transgene insertion 6, Christopher C Goodnow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053862
• toll-like receptor 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:96824

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tlr4<Lps-d>/Tlr4<Lps-d>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(IghelMD4)4Ccg|Tg(KLK4mHEL)6Ccg|Tlr4<Lps-d>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased B cell number
  http://purl.obolibrary.org/obo/MP_0005017

文献

http://purl.org/net/cito/citesAsAuthority

• Karlee. Silver, et.al., TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire., European journal of immunology, 2006, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/16703567