decreased T cell number_Lyve1<tm1.1(EGFP/cre)Cys>/Lyve1<+>,Sphk1<tm2Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>

http://metadb.riken.jp/0005018I129P2OlaHsd129S4SvJaeC57BL6Lyve1tm11EGFPcreCysLyve1Sphk1tm2CghSphk1tm2CghSphk2tm11CghSphk2tm11CghSphk2tm11CghLyve1tm11EGFPcreCysLyve1Sphk1tm2Cgh

decreased T cell number_Lyve1<tm1.1(EGFP/cre)Cys>/Lyve1<+>,Sphk1<tm2Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sphingosine kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1316649
• sphingosine kinase 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:1861380
• lymphatic vessel endothelial hyaluronan receptor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2136348

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lyve1<tm1.1(EGFP/cre)Cys>/Lyve1<+>,Sphk1<tm2Cgh>/Sphk1<tm2Cgh>,Sphk2<tm1.1Cgh>/Sphk2<tm1.1Cgh>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Sphk2<tm1.1Cgh>|Lyve1<tm1.1(EGFP/cre)Cys>|Lyve1<+>|Sphk1<tm2Cgh>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased T cell number
  http://purl.obolibrary.org/obo/MP_0005018

文献

http://purl.org/net/cito/citesAsAuthority

• Trung H M. Pham, et.al., Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning., The Journal of experimental medicine, 2010, 207
  http://rdf.ncbi.nlm.nih.gov/pubmed/20026661