decreased T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?

http://metadb.riken.jp/0005018I129S6SvEvTac129S7SvEvBrdC57BL6DBA2Foxo1tm1FlvFoxo1tm1FlvRag1tm1MomRag1tm1MomTgCD2Il7r1AsinTgCd4cre1CwiTgTcraTcrb425CbnFoxo1tm1FlvTgTcraTcrb425CbnRag1tm1MomTgCd4cre1CwiTgCD2Il7r1Asin

decreased T cell number_Foxo1<tm1Flv>/Foxo1<tm1Flv>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 425, Frank Carbone
  http://metadb.riken.jp/db/mgi_rdf/MGI:3046085
• forkhead box O1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1890077
• transgene insertion 1, Christopher B Wilson
  http://metadb.riken.jp/db/mgi_rdf/MGI:2448688
• recombination activating gene 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97848
• transgene insertion 1, Alfred Singer
  http://metadb.riken.jp/db/mgi_rdf/MGI:3763045

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Foxo1<tm1Flv>/Foxo1<tm1Flv>,Rag1<tm1Mom>/Rag1<tm1Mom>,Tg(CD2-Il7r)1Asin/?,Tg(Cd4-cre)1Cwi/?,Tg(TcraTcrb)425Cbn/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Foxo1<tm1Flv>|Tg(TcraTcrb)425Cbn|Rag1<tm1Mom>|Tg(Cd4-cre)1Cwi|Tg(CD2-Il7r)1Asin

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased T cell number
  http://purl.obolibrary.org/obo/MP_0005018

文献

http://purl.org/net/cito/citesAsAuthority

• Weiming. Ouyang, et.al., An essential role of the Forkhead-box transcription factor Foxo1 in control of T cell homeostasis and tolerance., Immunity, 2009, 30
  http://rdf.ncbi.nlm.nih.gov/pubmed/19285438