impaired granulocyte bactericidal activity_Itgam<tm1Myd>/Itgam<tm1Myd>,Syk<tm1Tyb>/Syk<tm1.2Tara>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0005074I129P2OlaHsd129S2SvPas129S4SvJaeC57BL6Itgamtm1MydItgamtm1MydSyktm1TybSyktm12TaraLyz2tm1creIfoLyz2Syktm1TybItgamtm1MydLyz2Lyz2tm1creIfoSyktm12Tara

impaired granulocyte bactericidal activity_Itgam<tm1Myd>/Itgam<tm1Myd>,Syk<tm1Tyb>/Syk<tm1.2Tara>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• spleen tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:99515
• integrin alpha M
  http://metadb.riken.jp/db/mgi_rdf/MGI:96607
• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Itgam<tm1Myd>/Itgam<tm1Myd>,Syk<tm1Tyb>/Syk<tm1.2Tara>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Syk<tm1Tyb>|Itgam<tm1Myd>|Lyz2<+>|Lyz2<tm1(cre)Ifo>|Syk<tm1.2Tara>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJae * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• impaired granulocyte bactericidal activity
  http://purl.obolibrary.org/obo/MP_0005074

文献

http://purl.org/net/cito/citesAsAuthority

• Jessica A. Van Ziffle, et.al., Neutrophil-specific deletion of Syk kinase results in reduced host defense to bacterial infection., Blood, 2009, 114
  http://rdf.ncbi.nlm.nih.gov/pubmed/19797524