decreased double-positive T cell number_Dyrk1a<tm1Jdc>/Dyrk1a<tm1Jdc>,Tg(Mx1-cre)1Cgn/0

http://metadb.riken.jp/0005092I129SvC57BL6JC57BL6NTacCBAJDyrk1atm1JdcDyrk1atm1JdcTgMx1cre1Cgn0TgMx1cre1CgnDyrk1atm1Jdc

decreased double-positive T cell number_Dyrk1a<tm1Jdc>/Dyrk1a<tm1Jdc>,Tg(Mx1-cre)1Cgn/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, University of Cologne
  http://metadb.riken.jp/db/mgi_rdf/MGI:2176072
• dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1330299

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Dyrk1a<tm1Jdc>/Dyrk1a<tm1Jdc>,Tg(Mx1-cre)1Cgn/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Mx1-cre)1Cgn|Dyrk1a<tm1Jdc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6J * C57BL/6NTac * CBA/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-positive T cell number
  http://purl.obolibrary.org/obo/MP_0005092

文献

http://purl.org/net/cito/citesAsAuthority

• Benjamin J. Thompson, et.al., DYRK1A controls the transition from proliferation to quiescence during lymphoid development by destabilizing Cyclin D3., The Journal of experimental medicine, 2015, 212
  http://rdf.ncbi.nlm.nih.gov/pubmed/26008897