decreased double-positive T cell number_Dock2<tm1Tsas>/Dock2<tm1Tsas>,Tg(Tcra2B4)1Mmd/?,Tg(Tcrb2B4)1Mmd/?

http://metadb.riken.jp/0005092IC57BL6Dock2tm1TsasDock2tm1TsasTgTcra2B41MmdTgTcrb2B41MmdTgTcrb2B41MmdTgTcra2B41MmdDock2tm1Tsas

decreased double-positive T cell number_Dock2<tm1Tsas>/Dock2<tm1Tsas>,Tg(Tcra2B4)1Mmd/?,Tg(Tcrb2B4)1Mmd/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• dedicator of cyto-kinesis 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:2149010
• transgene insertion 1, Mark M Davis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3688259
• transgene insertion 1, Mark M Davis
  http://metadb.riken.jp/db/mgi_rdf/MGI:3688260

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Dock2<tm1Tsas>/Dock2<tm1Tsas>,Tg(Tcra2B4)1Mmd/?,Tg(Tcrb2B4)1Mmd/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Tcrb2B4)1Mmd|Tg(Tcra2B4)1Mmd|Dock2<tm1Tsas>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased double-positive T cell number
  http://purl.obolibrary.org/obo/MP_0005092

文献

http://purl.org/net/cito/citesAsAuthority

• Terukazu. Sanui, et.al., DOCK2 is essential for antigen-induced translocation of TCR and lipid rafts, but not PKC-theta and LFA-1, in T cells., Immunity, 2003, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/12871644