decreased B cell proliferation_Btk<tm1Wk>/Btk<tm1Wk>,Tg(IGH-Btk)1Witt/0

http://metadb.riken.jp/0005093I129S4SvJae129X1SvJBALBcC3HC57BL6Btktm1WkBtktm1WkTgIGHBtk1Witt0TgIGHBtk1WittBtktm1Wk

decreased B cell proliferation_Btk<tm1Wk>/Btk<tm1Wk>,Tg(IGH-Btk)1Witt/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 1, Owen N Witte
  http://metadb.riken.jp/db/mgi_rdf/MGI:3836558
• Bruton agammaglobulinemia tyrosine kinase
  http://metadb.riken.jp/db/mgi_rdf/MGI:88216

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Btk<tm1Wk>/Btk<tm1Wk>,Tg(IGH-Btk)1Witt/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(IGH-Btk)1Witt|Btk<tm1Wk>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129X1/SvJ * BALB/c * C3H * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased B cell proliferation
  http://purl.obolibrary.org/obo/MP_0005093

文献

http://purl.org/net/cito/citesAsAuthority

• Lindsey R. Whyburn, et.al., Haploinsufficiency of B cell linker protein enhances B cell signaling defects in mice expressing a limiting dosage of Bruton's tyrosine kinase., International immunology, 2003, 15
  http://rdf.ncbi.nlm.nih.gov/pubmed/12618482