holoprosencephaly_Nog<tm1Amc>/Nog<+>,Smad3<tm1Xfw>/Smad3<tm1Xfw>

http://metadb.riken.jp/0005157I129Sv129S1SvNogtm1AmcNogSmad3tm1XfwSmad3tm1XfwSmad3tm1XfwNogNogtm1Amc

holoprosencephaly_Nog<tm1Amc>/Nog<+>,Smad3<tm1Xfw>/Smad3<tm1Xfw>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• SMAD family member 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:1201674
• noggin
  http://metadb.riken.jp/db/mgi_rdf/MGI:104327

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nog<tm1Amc>/Nog<+>,Smad3<tm1Xfw>/Smad3<tm1Xfw>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Smad3<tm1Xfw>|Nog<+>|Nog<tm1Amc>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * 129S1/Sv

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• holoprosencephaly
  http://purl.obolibrary.org/obo/MP_0005157

文献

http://purl.org/net/cito/citesAsAuthority

• Yu-Ping. Yang, et.al., BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning., Human molecular genetics, 2010, 19
  http://rdf.ncbi.nlm.nih.gov/pubmed/20508035