cardiac interstitial fibrosis_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

http://metadb.riken.jp/0005608I129SvC57BL6FVBNEif4ebp1tm1NsoEif4ebp1tm1NsoMtortm11GconMtortm11GconA1cfTgMyh6creEsr11Jmk0A1cfTgMyh6creEsr11JmkMtortm11GconEif4ebp1tm1Nso

cardiac interstitial fibrosis_Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• APOBEC1 complementation factor
  http://metadb.riken.jp/db/mgi_rdf/MGI:1917115
• eukaryotic translation initiation factor 4E binding protein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:103267
• mechanistic target of rapamycin (serine/threonine kinase)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1928394

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Eif4ebp1<tm1Nso>/Eif4ebp1<tm1Nso>,Mtor<tm1.1Gcon>/Mtor<tm1.1Gcon>,A1cf<Tg(Myh6-cre/Esr1*)1Jmk>/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• A1cf<Tg(Myh6-cre/Esr1*)1Jmk>|Mtor<tm1.1Gcon>|Eif4ebp1<tm1Nso>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129/Sv * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• cardiac interstitial fibrosis
  http://purl.obolibrary.org/obo/MP_0005608

文献

http://purl.org/net/cito/citesAsAuthority

• Denghong. Zhang, et.al., MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice., The Journal of clinical investigation, 2010, 120
  http://rdf.ncbi.nlm.nih.gov/pubmed/20644257