increased circulating leptin level_Lepr<tm1.1Chua>/Lepr<tm1.1Chua>,Tg(Pomc1-cre)16Lowl/0

http://metadb.riken.jp/0005669I129C57BL6JFVBLeprtm11ChuaLeprtm11ChuaTgPomc1cre16Lowl0Leprtm11ChuaTgPomc1cre16Lowl

increased circulating leptin level_Lepr<tm1.1Chua>/Lepr<tm1.1Chua>,Tg(Pomc1-cre)16Lowl/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• leptin receptor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104993
• transgene insertion 16, Bradford B Lowell
  http://metadb.riken.jp/db/mgi_rdf/MGI:3640615

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Lepr<tm1.1Chua>/Lepr<tm1.1Chua>,Tg(Pomc1-cre)16Lowl/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Lepr<tm1.1Chua>|Tg(Pomc1-cre)16Lowl

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6J * FVB

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased circulating leptin level
  http://purl.obolibrary.org/obo/MP_0005669

文献

http://purl.org/net/cito/citesAsAuthority

• Nina. Balthasar, et.al., Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis., Neuron, 2004, 42
  http://rdf.ncbi.nlm.nih.gov/pubmed/15207242
• Harveen. Dhillon, et.al., Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis., Neuron, 2006, 49
  http://rdf.ncbi.nlm.nih.gov/pubmed/16423694