embryonic lethality during organogenesis_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Sox2-cre)1Amc/0

http://metadb.riken.jp/0006207I129S5SvEvBrdC57BL6CBAGtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262LexWnk1GtOST38262LexTgSox2cre1Amc0TgSox2cre1AmcGtROSA26Sortm1Wnk1ClhuGtROSA26SorWnk1GtOST38262Lex

embryonic lethality during organogenesis_Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Sox2-cre)1Amc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• WNK lysine deficient protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442092
• transgene insertion 1, Andrew P McMahon
  http://metadb.riken.jp/db/mgi_rdf/MGI:2656537

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Wnk1)Clhu>/Gt(ROSA)26Sor<+>,Wnk1<Gt(OST38262)Lex>/Wnk1<Gt(OST38262)Lex>,Tg(Sox2-cre)1Amc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Sox2-cre)1Amc|Gt(ROSA)26Sor<tm1(Wnk1)Clhu>|Gt(ROSA)26Sor<+>|Wnk1<Gt(OST38262)Lex>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S5/SvEvBrd * C57BL/6 * CBA

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• embryonic lethality during organogenesis
  http://purl.obolibrary.org/obo/MP_0006207

文献

http://purl.org/net/cito/citesAsAuthority

• Jian. Xie, et.al., Endothelial-specific expression of WNK1 kinase is essential for angiogenesis and heart development in mice., The American journal of pathology, 2009, 175
  http://rdf.ncbi.nlm.nih.gov/pubmed/19644017