abnormal limb development_Fgfr1<tm1.1Jpa>/Fgfr1<+>,Gt(ROSA)26Sor<tm5(Etv4/en,-GFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre)1Cjt/0

http://metadb.riken.jp/0006279I129C57BL6CBASJLJSwissWebsterFgfr1tm11JpaFgfr1GtROSA26Sortm5Etv4enGFPAmcGtROSA26SorTgPrrx1cre1Cjt0TgPrrx1cre1CjtGtROSA26Sortm5Etv4enGFPAmcFgfr1tm11JpaGtROSA26SorFgfr1

abnormal limb development_Fgfr1<tm1.1Jpa>/Fgfr1<+>,Gt(ROSA)26Sor<tm5(Etv4/en,-GFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre)1Cjt/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• fibroblast growth factor receptor 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:95522
• transgene insertion 1, Clifford J Tabin
  http://metadb.riken.jp/db/mgi_rdf/MGI:2450928

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Fgfr1<tm1.1Jpa>/Fgfr1<+>,Gt(ROSA)26Sor<tm5(Etv4/en,-GFP)Amc>/Gt(ROSA)26Sor<+>,Tg(Prrx1-cre)1Cjt/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Prrx1-cre)1Cjt|Gt(ROSA)26Sor<tm5(Etv4/en,-GFP)Amc>|Fgfr1<tm1.1Jpa>|Gt(ROSA)26Sor<+>|Fgfr1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129 * C57BL/6 * CBA * SJL/J * Swiss Webster

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal limb development
  http://purl.obolibrary.org/obo/MP_0006279

文献

http://purl.org/net/cito/citesAsAuthority

• Junhao. Mao, et.al., Fgf-dependent Etv4/5 activity is required for posterior restriction of Sonic Hedgehog and promoting outgrowth of the vertebrate limb., Developmental cell, 2009, 16
  http://rdf.ncbi.nlm.nih.gov/pubmed/19386268