increased medulloblastoma incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Fabp7-cre,-lacZ)3Gtm/0

http://metadb.riken.jp/0006283I129P2OlaHsd129X1SvJCtnnb1tm1MmtCtnnb1Trp53tm1BrnTrp53TgFabp7crelacZ3Gtm0Trp53tm1BrnCtnnb1Ctnnb1tm1MmtTgFabp7crelacZ3GtmTrp53

increased medulloblastoma incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Fabp7-cre,-lacZ)3Gtm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• transgene insertion 3, David H Gutmann
  http://metadb.riken.jp/db/mgi_rdf/MGI:3810646
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<+>,Trp53<tm1Brn>/Trp53<+>,Tg(Fabp7-cre,-lacZ)3Gtm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brn>|Ctnnb1<+>|Ctnnb1<tm1Mmt>|Tg(Fabp7-cre,-lacZ)3Gtm|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased medulloblastoma incidence
  http://purl.obolibrary.org/obo/MP_0006283

文献

http://purl.org/net/cito/citesAsAuthority

• Giles. Robinson, et.al., Novel mutations target distinct subgroups of medulloblastoma., Nature, 2012, 488
  http://rdf.ncbi.nlm.nih.gov/pubmed/22722829