increased medulloblastoma incidence_Ptch1<tm1Cklr>/Ptch1<+>,Pax7<tm1(cre)Mrc>/Pax7<+>

http://metadb.riken.jp/0006283I129S1Sv129X1SvJC57BL6SJLPtch1tm1CklrPtch1Pax7tm1creMrcPax7Pax7tm1creMrcPtch1Pax7Ptch1tm1Cklr

increased medulloblastoma incidence_Ptch1<tm1Cklr>/Ptch1<+>,Pax7<tm1(cre)Mrc>/Pax7<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• patched 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:105373
• paired box 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:97491

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ptch1<tm1Cklr>/Ptch1<+>,Pax7<tm1(cre)Mrc>/Pax7<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pax7<tm1(cre)Mrc>|Ptch1<+>|Pax7<+>|Ptch1<tm1Cklr>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased medulloblastoma incidence
  http://purl.obolibrary.org/obo/MP_0006283

文献

http://purl.org/net/cito/citesAsAuthority

• Eri. Taniguchi, et.al., Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma., Pediatric blood & cancer, 2009, 53
  http://rdf.ncbi.nlm.nih.gov/pubmed/19213072