early cellular replicative senescence_Gt(ROSA)26Sor<tm1(cre/ERT)Brn>/Gt(ROSA)26Sor<+>,Ppp1r13l<tm1Xlu>/Ppp1r13l<tm1Xlu>

http://metadb.riken.jp/0008008I129P2OlaHsd129SSvEvC57BL6JGtROSA26Sortm1creERTBrnGtROSA26SorPpp1r13ltm1XluPpp1r13ltm1XluGtROSA26Sortm1creERTBrnGtROSA26SorPpp1r13ltm1Xlu

early cellular replicative senescence_Gt(ROSA)26Sor<tm1(cre/ERT)Brn>/Gt(ROSA)26Sor<+>,Ppp1r13l<tm1Xlu>/Ppp1r13l<tm1Xlu>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• protein phosphatase 1, regulatory (inhibitor) subunit 13 like
  http://metadb.riken.jp/db/mgi_rdf/MGI:3525053
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(cre/ERT)Brn>/Gt(ROSA)26Sor<+>,Ppp1r13l<tm1Xlu>/Ppp1r13l<tm1Xlu>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(cre/ERT)Brn>|Gt(ROSA)26Sor<+>|Ppp1r13l<tm1Xlu>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• early cellular replicative senescence
  http://purl.obolibrary.org/obo/MP_0008008

文献

http://purl.org/net/cito/citesAsAuthority

• Mario. Notari, et.al., Inhibitor of apoptosis-stimulating protein of p53 (iASPP) prevents senescence and is required for epithelial stratification., Proceedings of the National Academy of Sciences of the United States of America, 2011, 108
  http://rdf.ncbi.nlm.nih.gov/pubmed/21930934