increased lung tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Upk2-cre)6Xrw/0

http://metadb.riken.jp/0008014I129S6SvEvTac129X1SvJFVBNCtnnb1tm1MmtCtnnb1Fgfr3tm4CxdFgfr3TgUpk2cre6Xrw0Fgfr3tm4CxdTgUpk2cre6XrwCtnnb1tm1MmtCtnnb1Fgfr3

increased lung tumor incidence_Ctnnb1<tm1Mmt>/Ctnnb1<+>,Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Upk2-cre)6Xrw/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• catenin (cadherin associated protein), beta 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:88276
• fibroblast growth factor receptor 3
  http://metadb.riken.jp/db/mgi_rdf/MGI:95524
• transgene insertion 6, Xue-Ru Wu
  http://metadb.riken.jp/db/mgi_rdf/MGI:3583892

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Ctnnb1<tm1Mmt>/Ctnnb1<+>,Fgfr3<tm4Cxd>/Fgfr3<+>,Tg(Upk2-cre)6Xrw/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Fgfr3<tm4Cxd>|Tg(Upk2-cre)6Xrw|Ctnnb1<tm1Mmt>|Ctnnb1<+>|Fgfr3<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased lung tumor incidence
  http://purl.obolibrary.org/obo/MP_0008014

文献

http://purl.org/net/cito/citesAsAuthority

• Imran. Ahmad, et.al., K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder., Disease models & mechanisms, 2011, 4
  http://rdf.ncbi.nlm.nih.gov/pubmed/21504907