retinal ganglion cell degeneration_Isl1<tm2Gan>/Isl1<tm2Gan>,Pou4f2<tm1(ALPP)Whk>/Pou4f2<tm2Whk>,Tg(Six3-cre)69Frty/?

http://metadb.riken.jp/0008067I129S6SvEvTacC57BL6DBA2Isl1tm2GanIsl1tm2GanPou4f2tm1ALPPWhkPou4f2tm2WhkTgSix3cre69FrtyPou4f2tm2WhkIsl1tm2GanPou4f2tm1ALPPWhkTgSix3cre69Frty

retinal ganglion cell degeneration_Isl1<tm2Gan>/Isl1<tm2Gan>,Pou4f2<tm1(ALPP)Whk>/Pou4f2<tm2Whk>,Tg(Six3-cre)69Frty/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• POU domain, class 4, transcription factor 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:102524
• transgene insertion 69, Yasuhide Furuta
  http://metadb.riken.jp/db/mgi_rdf/MGI:3574770
• ISL1 transcription factor, LIM/homeodomain
  http://metadb.riken.jp/db/mgi_rdf/MGI:101791

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Isl1<tm2Gan>/Isl1<tm2Gan>,Pou4f2<tm1(ALPP)Whk>/Pou4f2<tm2Whk>,Tg(Six3-cre)69Frty/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Pou4f2<tm2Whk>|Isl1<tm2Gan>|Pou4f2<tm1(ALPP)Whk>|Tg(Six3-cre)69Frty

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• retinal ganglion cell degeneration
  http://purl.obolibrary.org/obo/MP_0008067

文献

http://purl.org/net/cito/citesAsAuthority

• Ling. Pan, et.al., ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells., Development (Cambridge, England), 2008, 135
  http://rdf.ncbi.nlm.nih.gov/pubmed/18434421