decreased CD4-positive, alpha beta T cell number_Mcl1<tm1Yen>/Mcl1<tm1Yen>,Tg(TcraTcrb)425Cbn/?

http://metadb.riken.jp/0008075I129S1Sv129X1SvJC57BL6Mcl1tm1YenMcl1tm1YenTgTcraTcrb425CbnMcl1tm1YenTgTcraTcrb425Cbn

decreased CD4-positive, alpha beta T cell number_Mcl1<tm1Yen>/Mcl1<tm1Yen>,Tg(TcraTcrb)425Cbn/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 425, Frank Carbone
  http://metadb.riken.jp/db/mgi_rdf/MGI:3046085
• myeloid cell leukemia sequence 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:101769

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mcl1<tm1Yen>/Mcl1<tm1Yen>,Tg(TcraTcrb)425Cbn/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mcl1<tm1Yen>|Tg(TcraTcrb)425Cbn

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased CD4-positive, alpha beta T cell number
  http://purl.obolibrary.org/obo/MP_0008075

文献

http://purl.org/net/cito/citesAsAuthority

• Chia-Yu. Yang, et.al., Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression., Journal of immunology (Baltimore, Md. : 1950), 2009, 182
  http://rdf.ncbi.nlm.nih.gov/pubmed/19234191