decreased mature B cell number_Tlr9<tm1Aki>/Tlr9<tm1Aki>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

http://metadb.riken.jp/0008211I129P2OlaHsdC57BL6Tlr9tm1AkiTlr9tm1AkiTgIghelMD44Ccg0TgKLK4mHEL6Ccg0TgKLK4mHEL6CcgTgIghelMD44CcgTlr9tm1Aki

decreased mature B cell number_Tlr9<tm1Aki>/Tlr9<tm1Aki>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 6, Christopher C Goodnow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053862
• transgene insertion 4, Christopher C Goodnow
  http://metadb.riken.jp/db/mgi_rdf/MGI:3053738
• toll-like receptor 9
  http://metadb.riken.jp/db/mgi_rdf/MGI:1932389

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tlr9<tm1Aki>/Tlr9<tm1Aki>,Tg(IghelMD4)4Ccg/0,Tg(KLK4mHEL)6Ccg/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(KLK4mHEL)6Ccg|Tg(IghelMD4)4Ccg|Tlr9<tm1Aki>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mature B cell number
  http://purl.obolibrary.org/obo/MP_0008211

文献

http://purl.org/net/cito/citesAsAuthority

• Karlee. Silver, et.al., TLR4, TLR9 and MyD88 are not required for the positive selection of autoreactive B cells into the primary repertoire., European journal of immunology, 2006, 36
  http://rdf.ncbi.nlm.nih.gov/pubmed/16703567