decreased mature B cell number_Igh-J<tm1Jkbv>/Igh-J<tm1Jkbv>,Igkc<tm1Jkbv>/Igkc<tm1Jkbv>,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv

http://metadb.riken.jp/0008211I129P2OlaHsdIghJtm1JkbvIghJtm1JkbvIgkctm1JkbvIgkctm1JkbvTgIGHyH12BJkbvTgIGHyH12BJkbvTgIGKyK192CJkbvTgIGKyK192CJkbvTgIGKyK192CJkbvIgkctm1JkbvTgIGHyH12BJkbvIghJtm1Jkbv

decreased mature B cell number_Igh-J<tm1Jkbv>/Igh-J<tm1Jkbv>,Igkc<tm1Jkbv>/Igkc<tm1Jkbv>,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 2B, Aya Jakobovits
  http://metadb.riken.jp/db/mgi_rdf/MGI:3802670
• immunoglobulin kappa constant
  http://metadb.riken.jp/db/mgi_rdf/MGI:96495
• transgene insertion 9.2C, Aya Jakobovits
  http://metadb.riken.jp/db/mgi_rdf/MGI:3802673
• immunoglobulin heavy chain, joining region
  http://metadb.riken.jp/db/mgi_rdf/MGI:96461

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Igh-J<tm1Jkbv>/Igh-J<tm1Jkbv>,Igkc<tm1Jkbv>/Igkc<tm1Jkbv>,Tg(IGH@yH1)2BJkbv/Tg(IGH@yH1)2BJkbv,Tg(IGK@yK1)9.2CJkbv/Tg(IGK@yK1)9.2CJkbv

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(IGK@yK1)9.2CJkbv|Igkc<tm1Jkbv>|Tg(IGH@yH1)2BJkbv|Igh-J<tm1Jkbv>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mature B cell number
  http://purl.obolibrary.org/obo/MP_0008211

文献

http://purl.org/net/cito/citesAsAuthority

• L L. Green, et.al., Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes., The Journal of experimental medicine, 1998, 188
  http://rdf.ncbi.nlm.nih.gov/pubmed/9687526