decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>

http://metadb.riken.jp/0008211I129S1Sv129S2SvPas129S6SvEvTacC57BL6Vav1tm1TybVav1tm1TybVav2tm1KdfVav2tm1KdfVav3tm1SwatVav3tm1SwatVav2tm1KdfVav3tm1SwatVav1tm1Tyb

decreased mature B cell number_Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• vav 1 oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:98923
• vav 3 oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:1888518
• vav 2 oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:102718

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Vav1<tm1Tyb>/Vav1<tm1Tyb>,Vav2<tm1Kdf>/Vav2<tm1Kdf>,Vav3<tm1Swat>/Vav3<tm1Swat>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Vav2<tm1Kdf>|Vav3<tm1Swat>|Vav1<tm1Tyb>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S2/SvPas * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased mature B cell number
  http://purl.obolibrary.org/obo/MP_0008211

文献

http://purl.org/net/cito/citesAsAuthority

• Keiko. Fujikawa, et.al., Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells., The Journal of experimental medicine, 2003, 198
  http://rdf.ncbi.nlm.nih.gov/pubmed/14623913