increased susceptibility to neuronal excitotoxicity_Nudt1<tm1Tts>/Nudt1<tm1Tts>,Ogg1<tm1Skmi>/Ogg1<tm1Skmi>

http://metadb.riken.jp/0008235I129SSvEvC57BL6JJclNudt1tm1TtsNudt1tm1TtsOgg1tm1SkmiOgg1tm1SkmiNudt1tm1TtsOgg1tm1Skmi

increased susceptibility to neuronal excitotoxicity_Nudt1<tm1Tts>/Nudt1<tm1Tts>,Ogg1<tm1Skmi>/Ogg1<tm1Skmi>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• nudix (nucleoside diphosphate linked moiety X)-type motif 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:109280
• 8-oxoguanine DNA-glycosylase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:1097693

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Nudt1<tm1Tts>/Nudt1<tm1Tts>,Ogg1<tm1Skmi>/Ogg1<tm1Skmi>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Nudt1<tm1Tts>|Ogg1<tm1Skmi>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S/SvEv * C57BL/6JJcl

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to neuronal excitotoxicity
  http://purl.obolibrary.org/obo/MP_0008235

文献

http://purl.org/net/cito/citesAsAuthority

• Zijing. Sheng, et.al., 8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/23143307