increased cellular sensitivity to oxidative stress_n-TUtca2<tm2Mym>/n-TUtca2<tm2.1Mym>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

http://metadb.riken.jp/0008412I129P2OlaHsdC57BL6DBA2nTUtca2tm2MymnTUtca2tm21MymLyz2tm1creIfoLyz2nTUtca2tm2MymnTUtca2tm21MymLyz2tm1creIfoLyz2

increased cellular sensitivity to oxidative stress_n-TUtca2<tm2Mym>/n-TUtca2<tm2.1Mym>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• lysozyme 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:96897
• nuclear encoded tRNA selenocysteine 2 (anticodon TCA)
  http://metadb.riken.jp/db/mgi_rdf/MGI:4414022

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• n-TUtca2<tm2Mym>/n-TUtca2<tm2.1Mym>,Lyz2<tm1(cre)Ifo>/Lyz2<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• n-TUtca2<tm2Mym>|n-TUtca2<tm2.1Mym>|Lyz2<tm1(cre)Ifo>|Lyz2<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased cellular sensitivity to oxidative stress
  http://purl.obolibrary.org/obo/MP_0008412

文献

http://purl.org/net/cito/citesAsAuthority

• Takafumi. Suzuki, et.al., Deletion of the selenocysteine tRNA gene in macrophages and liver results in compensatory gene induction of cytoprotective enzymes by Nrf2., The Journal of biological chemistry, 2008, 283
  http://rdf.ncbi.nlm.nih.gov/pubmed/18039655