abnormal neurite morphology_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Map2k7<tm1Rjd>/Map2k7<tm1Rjd>,Tg(APPswe,PSEN1dE9)85Dbo/0,Tg(Camk2a-cre/ERT2)2Gsc/0

http://metadb.riken.jp/0008415IC3HC57BL6FVBNMap2k4tm1CtrMap2k4tm1CtrMap2k7tm1RjdMap2k7tm1RjdTgAPPswePSEN1dE985Dbo0TgCamk2acreERT22Gsc0Map2k4tm1CtrMap2k7tm1RjdTgCamk2acreERT22GscTgAPPswePSEN1dE985Dbo

abnormal neurite morphology_Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Map2k7<tm1Rjd>/Map2k7<tm1Rjd>,Tg(APPswe,PSEN1dE9)85Dbo/0,Tg(Camk2a-cre/ERT2)2Gsc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• mitogen-activated protein kinase kinase 7
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346871
• transgene insertion 85, David R Borchelt
  http://metadb.riken.jp/db/mgi_rdf/MGI:3525178
• transgene insertion 2, Gunther Schutz
  http://metadb.riken.jp/db/mgi_rdf/MGI:3759303
• mitogen-activated protein kinase kinase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:1346869

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Map2k4<tm1Ctr>/Map2k4<tm1Ctr>,Map2k7<tm1Rjd>/Map2k7<tm1Rjd>,Tg(APPswe,PSEN1dE9)85Dbo/0,Tg(Camk2a-cre/ERT2)2Gsc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Map2k4<tm1Ctr>|Map2k7<tm1Rjd>|Tg(Camk2a-cre/ERT2)2Gsc|Tg(APPswe,PSEN1dE9)85Dbo

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: C3H * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• abnormal neurite morphology
  http://purl.obolibrary.org/obo/MP_0008415

文献

http://purl.org/net/cito/citesAsAuthority

• Sonia. Mazzitelli, et.al., The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/22114267