decreased spleen germinal center number_Icos<tm1Mak>/Icos<tm1Mak>

http://metadb.riken.jp/0008482I129P2OlaHsdC57BL6Icostm1MakIcostm1MakIcostm1Mak

decreased spleen germinal center number_Icos<tm1Mak>/Icos<tm1Mak>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• inducible T cell co-stimulator
  http://metadb.riken.jp/db/mgi_rdf/MGI:1858745

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Icos<tm1Mak>/Icos<tm1Mak>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Icos<tm1Mak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased spleen germinal center number
  http://purl.obolibrary.org/obo/MP_0008482

文献

http://purl.org/net/cito/citesAsAuthority

• A. Tafuri, et.al., ICOS is essential for effective T-helper-cell responses., Nature, 2001, 409
  http://rdf.ncbi.nlm.nih.gov/pubmed/11343123
• Mathieu. Gigoux, et.al., Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase., Proceedings of the National Academy of Sciences of the United States of America, 2009, 106
  http://rdf.ncbi.nlm.nih.gov/pubmed/19915142