decreased spleen germinal center size_Gt(ROSA)26Sor<tm12(CD2*)Rsky>/Gt(ROSA)26Sor<+>,Myc<tm2Fwa>/Myc<tm2Fwa>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

http://metadb.riken.jp/0008484I129P2OlaHsd129S6SvEvTacC57BL6GtROSA26Sortm12CD2RskyGtROSA26SorMyctm2FwaMyctm2FwaIghg1tm1creCgnIghg1GtROSA26SorGtROSA26Sortm12CD2RskyMyctm2FwaIghg1tm1creCgnIghg1

decreased spleen germinal center size_Gt(ROSA)26Sor<tm12(CD2*)Rsky>/Gt(ROSA)26Sor<+>,Myc<tm2Fwa>/Myc<tm2Fwa>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• myelocytomatosis oncogene
  http://metadb.riken.jp/db/mgi_rdf/MGI:97250
• immunoglobulin heavy constant gamma 1 (G1m marker)
  http://metadb.riken.jp/db/mgi_rdf/MGI:96446
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm12(CD2*)Rsky>/Gt(ROSA)26Sor<+>,Myc<tm2Fwa>/Myc<tm2Fwa>,Ighg1<tm1(cre)Cgn>/Ighg1<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm12(CD2*)Rsky>|Myc<tm2Fwa>|Ighg1<tm1(cre)Cgn>|Ighg1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased spleen germinal center size
  http://purl.obolibrary.org/obo/MP_0008484

文献

http://purl.org/net/cito/citesAsAuthority

• Dinis Pedro. Calado, et.al., The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers., Nature immunology, 2012, 13
  http://rdf.ncbi.nlm.nih.gov/pubmed/23001146