increased tumor necrosis factor secretion_Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Lck-cre)I57Jxm/0

http://metadb.riken.jp/0008560I129S6SvEvTacICRGtROSA26Sortm2ITKSykHjumGtROSA26SorTgLckcreI57Jxm0TgLckcreI57JxmGtROSA26SorGtROSA26Sortm2ITKSykHjum

increased tumor necrosis factor secretion_Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Lck-cre)I57Jxm/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion I57, Jamey Marth
  http://metadb.riken.jp/db/mgi_rdf/MGI:2177579

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>/Gt(ROSA)26Sor<+>,Tg(Lck-cre)I57Jxm/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(Lck-cre)I57Jxm|Gt(ROSA)26Sor<+>|Gt(ROSA)26Sor<tm2(ITK/Syk)Hjum>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * ICR

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased tumor necrosis factor secretion
  http://purl.obolibrary.org/obo/MP_0008560

文献

http://purl.org/net/cito/citesAsAuthority

• Martina P. Bach, et.al., Premature terminal differentiation protects from deregulated lymphocyte activation by ITK-Syk., Journal of immunology (Baltimore, Md. : 1950), 2014, 192
  http://rdf.ncbi.nlm.nih.gov/pubmed/24376268