increased interleukin-12 secretion_Mefv<tm5.1(MEFV)Chae>/Mefv<tm5.1(MEFV)Chae>,Rag1<tm1Mom>/Rag1<tm1Mom>

http://metadb.riken.jp/0008663I129S6SvEvTac129S7SvEvBrdC57BL6Mefvtm51MEFVChaeMefvtm51MEFVChaeRag1tm1MomRag1tm1MomRag1tm1MomMefvtm51MEFVChae

increased interleukin-12 secretion_Mefv<tm5.1(MEFV)Chae>/Mefv<tm5.1(MEFV)Chae>,Rag1<tm1Mom>/Rag1<tm1Mom>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• recombination activating gene 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97848
• Mediterranean fever
  http://metadb.riken.jp/db/mgi_rdf/MGI:1859396

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mefv<tm5.1(MEFV)Chae>/Mefv<tm5.1(MEFV)Chae>,Rag1<tm1Mom>/Rag1<tm1Mom>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rag1<tm1Mom>|Mefv<tm5.1(MEFV)Chae>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased interleukin-12 secretion
  http://purl.obolibrary.org/obo/MP_0008663

文献

http://purl.org/net/cito/citesAsAuthority

• Jae Jin. Chae, et.al., Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice., Immunity, 2011, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/21600797