increased susceptibility to endotoxin shock_Usp18<ity9>/Usp18<ity9>

http://metadb.riken.jp/0008735I129S1SvImJC57BL6Usp18ity9Usp18ity9Usp18ity9

increased susceptibility to endotoxin shock_Usp18<ity9>/Usp18<ity9>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• ubiquitin specific peptidase 18
  http://metadb.riken.jp/db/mgi_rdf/MGI:1344364

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Usp18<ity9>/Usp18<ity9>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Usp18<ity9>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/SvImJ * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased susceptibility to endotoxin shock
  http://purl.obolibrary.org/obo/MP_0008735

文献

http://purl.org/net/cito/citesAsAuthority

• Etienne. Richer, et.al., N-ethyl-N-nitrosourea-induced mutation in ubiquitin-specific peptidase 18 causes hyperactivation of IFN-αß signaling and suppresses STAT4-induced IFN-γ production, resulting in increased susceptibility to Salmonella typhimurium., Journal of immunology (Baltimore, Md. : 1950), 2010, 185
  http://rdf.ncbi.nlm.nih.gov/pubmed/20693420