increased physiological sensitivity to xenobiotic_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>

http://metadb.riken.jp/0008873129S7SvEvBrdMt1tm1BriMt2tm1BriJMt1tm1BriMt1tm1BriMt2tm1BriMt2tm1BriMt1tm1BriMt2tm1Bri

increased physiological sensitivity to xenobiotic_Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• metallothionein 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:97171
• metallothionein 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:97172

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Mt1<tm1Bri>/Mt1<tm1Bri>,Mt2<tm1Bri>/Mt2<tm1Bri>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Mt1<tm1Bri>|Mt2<tm1Bri>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• 129S7/SvEvBrd-Mt1<tm1Bri> Mt2<tm1Bri>/J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008873

文献

http://purl.org/net/cito/citesAsAuthority

• Y. Liu, et.al., Metallothionein-I/II null mice are sensitive to chronic oral cadmium-induced nephrotoxicity., Toxicological sciences : an official journal of the Society of Toxicology, 2000, 57
  http://rdf.ncbi.nlm.nih.gov/pubmed/10966523
• S S. Habeebu, et.al., Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury., Toxicological sciences : an official journal of the Society of Toxicology, 2000, 56
  http://rdf.ncbi.nlm.nih.gov/pubmed/10869470
• Scott C. Wesselkamper, et.al., The role of metallothionein in the pathogenesis of acute lung injury., American journal of respiratory cell and molecular biology, 2006, 34
  http://rdf.ncbi.nlm.nih.gov/pubmed/16166738
• J. Carrasco, et.al., Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice., The European journal of neuroscience, 2000, 12
  http://rdf.ncbi.nlm.nih.gov/pubmed/10947810