decreased physiological sensitivity to xenobiotic_Cyp1a2<tm1Dwn>/Cyp1a2<tm1Dwn>

http://metadb.riken.jp/0008874B6129P2Cyp1a2tm1DwnCyp1a2tm1DwnCyp1a2tm1DwnCyp1a2tm1Dwn

decreased physiological sensitivity to xenobiotic_Cyp1a2<tm1Dwn>/Cyp1a2<tm1Dwn>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• cytochrome P450, family 1, subfamily a, polypeptide 2
  http://metadb.riken.jp/db/mgi_rdf/MGI:88589

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cyp1a2<tm1Dwn>/Cyp1a2<tm1Dwn>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cyp1a2<tm1Dwn>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.129P2-Cyp1a2<tm1Dwn>

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008874

文献

http://purl.org/net/cito/citesAsAuthority

• P R. Sinclair, et.al., CYP1A2 is essential in murine uroporphyria caused by hexachlorobenzene and iron., Toxicology and applied pharmacology, 2000, 162
  http://rdf.ncbi.nlm.nih.gov/pubmed/10631128
• Peter. Greaves, et.al., Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse., Biochemical and biophysical research communications, 2005, 331
  http://rdf.ncbi.nlm.nih.gov/pubmed/15845371