decreased physiological sensitivity to xenobiotic_Wnk1<tm1.1Juha>/Wnk1<tm1.1Juha>

http://metadb.riken.jp/0008874I129S2SvPasC57BL6C57BL6NSJLWnk1tm11JuhaWnk1tm11JuhaWnk1tm11Juha

decreased physiological sensitivity to xenobiotic_Wnk1<tm1.1Juha>/Wnk1<tm1.1Juha>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• WNK lysine deficient protein kinase 1
  http://metadb.riken.jp/db/mgi_rdf/MGI:2442092

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Wnk1<tm1.1Juha>/Wnk1<tm1.1Juha>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Wnk1<tm1.1Juha>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S2/SvPas * C57BL/6 * C57BL/6N * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased physiological sensitivity to xenobiotic
  http://purl.obolibrary.org/obo/MP_0008874

文献

http://purl.org/net/cito/citesAsAuthority

• Juliette. Hadchouel, et.al., Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension., Proceedings of the National Academy of Sciences of the United States of America, 2010, 107
  http://rdf.ncbi.nlm.nih.gov/pubmed/20921400