reticulocytopenia_Hbb-b1<tm1Unc>/Hbb-b1<+>,Hbb-b2<tm1Unc>/Hbb-b2<+>,Tmprss6<tm1Otin>/Tmprss6<tm1Otin>

http://metadb.riken.jp/0008941I129P2OlaHsdC57BL6C57BL6NHbbb1tm1UncHbbb1Hbbb2tm1UncHbbb2Tmprss6tm1OtinTmprss6tm1OtinHbbb2Tmprss6tm1OtinHbbb1tm1UncHbbb2tm1UncHbbb1

reticulocytopenia_Hbb-b1<tm1Unc>/Hbb-b1<+>,Hbb-b2<tm1Unc>/Hbb-b2<+>,Tmprss6<tm1Otin>/Tmprss6<tm1Otin>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transmembrane serine protease 6
  http://metadb.riken.jp/db/mgi_rdf/MGI:1919003
• hemoglobin, beta adult minor chain
  http://metadb.riken.jp/db/mgi_rdf/MGI:96022
• hemoglobin, beta adult major chain
  http://metadb.riken.jp/db/mgi_rdf/MGI:96021

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Hbb-b1<tm1Unc>/Hbb-b1<+>,Hbb-b2<tm1Unc>/Hbb-b2<+>,Tmprss6<tm1Otin>/Tmprss6<tm1Otin>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Hbb-b2<+>|Tmprss6<tm1Otin>|Hbb-b1<tm1Unc>|Hbb-b2<tm1Unc>|Hbb-b1<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• reticulocytopenia
  http://purl.obolibrary.org/obo/MP_0008941

文献

http://purl.org/net/cito/citesAsAuthority

• Antonella. Nai, et.al., Deletion of TMPRSS6 attenuates the phenotype in a mouse model of β-thalassemia., Blood, 2012, 119
  http://rdf.ncbi.nlm.nih.gov/pubmed/22490684