decreased neuron number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Rest<tm1.1Jhsi>/Rest<tm1.1Jhsi>,Tg(Nes-cre/ERT2)KEisc/0

http://metadb.riken.jp/0008948I129S6SvEvTac129X1SvJC57BL6SJLGtROSA26Sortm1EYFPCosGtROSA26SorResttm11JhsiResttm11JhsiTgNescreERT2KEisc0Resttm11JhsiTgNescreERT2KEiscGtROSA26Sortm1EYFPCosGtROSA26Sor

decreased neuron number_Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Rest<tm1.1Jhsi>/Rest<tm1.1Jhsi>,Tg(Nes-cre/ERT2)KEisc/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• RE1-silencing transcription factor
  http://metadb.riken.jp/db/mgi_rdf/MGI:104897
• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion K, Amelia Eisch
  http://metadb.riken.jp/db/mgi_rdf/MGI:3767426

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(EYFP)Cos>/Gt(ROSA)26Sor<+>,Rest<tm1.1Jhsi>/Rest<tm1.1Jhsi>,Tg(Nes-cre/ERT2)KEisc/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Rest<tm1.1Jhsi>|Tg(Nes-cre/ERT2)KEisc|Gt(ROSA)26Sor<tm1(EYFP)Cos>|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * SJL

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• decreased neuron number
  http://purl.obolibrary.org/obo/MP_0008948

文献

http://purl.org/net/cito/citesAsAuthority

• Zhengliang. Gao, et.al., The master negative regulator REST/NRSF controls adult neurogenesis by restraining the neurogenic program in quiescent stem cells., The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, 31
  http://rdf.ncbi.nlm.nih.gov/pubmed/21715642