increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm1Gev>/Trp53<tm1Gev>

http://metadb.riken.jp/0009151I129P2OlaHsd129S4SvJaeC57BL6FVBNKrastm4TyjKrasTgPdx1cre6Tuv0Trp53tm1GevTrp53tm1GevKrasTgPdx1cre6TuvKrastm4TyjTrp53tm1Gev

increased pancreatic ductal adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm1Gev>/Trp53<tm1Gev>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 6, David A Tuveson
  http://metadb.riken.jp/db/mgi_rdf/MGI:5437123
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Tg(Pdx1-cre)6Tuv/0,Trp53<tm1Gev>/Trp53<tm1Gev>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Kras<+>|Tg(Pdx1-cre)6Tuv|Kras<tm4Tyj>|Trp53<tm1Gev>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Daniel. Massó-Vallés, et.al., Ibrutinib exerts potent antifibrotic and antitumor activities in mouse models of pancreatic adenocarcinoma., Cancer research, 2015, 75
  http://rdf.ncbi.nlm.nih.gov/pubmed/25878147