increased pancreatic ductal adenocarcinoma incidence_Kras<tm1Bbd>/Kras<+>,Trp53<tm1Brd>/Trp53<+>,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?

http://metadb.riken.jp/0009151I129S1Sv129S7SvEvBrd129X1SvJFVBNKrastm1BbdKrasTrp53tm1BrdTrp53TgCela1tTAEpsTgtetOcre3JigTrp53tm1BrdKrastm1BbdKrasTgtetOcre3JigTgCela1tTAEpsTrp53

increased pancreatic ductal adenocarcinoma incidence_Kras<tm1Bbd>/Kras<+>,Trp53<tm1Brd>/Trp53<+>,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 3, Jeffrey I Gordon
  http://metadb.riken.jp/db/mgi_rdf/MGI:3041442
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834
• transgene insertion, Eric P Sandgren
  http://metadb.riken.jp/db/mgi_rdf/MGI:5502416
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm1Bbd>/Kras<+>,Trp53<tm1Brd>/Trp53<+>,Tg(Cela1-tTA)#Eps/?,Tg(tetO-cre)3Jig/?

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Trp53<tm1Brd>|Kras<tm1Bbd>|Kras<+>|Tg(tetO-cre)3Jig|Tg(Cela1-tTA)#Eps|Trp53<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Carmen. Guerra, et.al., Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice., Cancer cell, 2007, 11
  http://rdf.ncbi.nlm.nih.gov/pubmed/17349585