increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Tva)Dsa>/Gt(ROSA)26Sor<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

http://metadb.riken.jp/0009151I129S4SvJae129S6SvEvTacC57BL6JGtROSA26Sortm1TvaDsaGtROSA26SorKrastm4TyjKrasPtf1atm1creHnakPtf1aPtf1aGtROSA26SorKrastm4TyjKrasPtf1atm1creHnakGtROSA26Sortm1TvaDsa

increased pancreatic ductal adenocarcinoma incidence_Gt(ROSA)26Sor<tm1(Tva)Dsa>/Gt(ROSA)26Sor<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(Tva)Dsa>/Gt(ROSA)26Sor<+>,Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<+>|Gt(ROSA)26Sor<+>|Kras<tm4Tyj>|Kras<+>|Ptf1a<tm1(cre)Hnak>|Gt(ROSA)26Sor<tm1(Tva)Dsa>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6J

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic ductal adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009151

文献

http://purl.org/net/cito/citesAsAuthority

• Barbara. Seidler, et.al., A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors., Proceedings of the National Academy of Sciences of the United States of America, 2008, 105
  http://rdf.ncbi.nlm.nih.gov/pubmed/18621715