increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<tm4Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

http://metadb.riken.jp/0009152I129S4SvJaeKrastm4TyjKrastm4TyjPtf1atm1creHnakPtf1aPtf1aKrastm4TyjPtf1atm1creHnak

increased pancreatic intraepithelial neoplasia incidence_Kras<tm4Tyj>/Kras<tm4Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<tm4Tyj>,Ptf1a<tm1(cre)Hnak>/Ptf1a<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Ptf1a<+>|Kras<tm4Tyj>|Ptf1a<tm1(cre)Hnak>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJae

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreatic intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009152

文献

http://purl.org/net/cito/citesAsAuthority

• S. Beilke, et.al., The zinc-finger protein KCMF1 is overexpressed during pancreatic cancer development and downregulation of KCMF1 inhibits pancreatic cancer development in mice., Oncogene, 2010, 29
  http://rdf.ncbi.nlm.nih.gov/pubmed/20473331