increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MUC1)79.24Gend/0

http://metadb.riken.jp/0009153B6CgKrastm4TyjPtf1atm11creCvwTgMUC17924GendKrastm4TyjKrasPtf1atm11creCvwPtf1aTgMUC17924Gend0TgMUC17924GendPtf1atm11creCvwKrastm4TyjKrasPtf1a

increased pancreas tumor incidence_Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MUC1)79.24Gend/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• pancreas specific transcription factor, 1a
  http://metadb.riken.jp/db/mgi_rdf/MGI:1328312
• transgene insertion 79.24, Sandra J Gendler
  http://metadb.riken.jp/db/mgi_rdf/MGI:3777620
• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Ptf1a<tm1.1(cre)Cvw>/Ptf1a<+>,Tg(MUC1)79.24Gend/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tg(MUC1)79.24Gend|Ptf1a<tm1.1(cre)Cvw>|Kras<tm4Tyj>|Kras<+>|Ptf1a<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• B6.Cg-Kras<tm4Tyj> Ptf1a<tm1.1(cre)Cvw> Tg(MUC1)79.24Gend

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased pancreas tumor incidence
  http://purl.obolibrary.org/obo/MP_0009153

文献

http://purl.org/net/cito/citesAsAuthority

• Teresa L. Tinder, et.al., MUC1 enhances tumor progression and contributes toward immunosuppression in a mouse model of spontaneous pancreatic adenocarcinoma., Journal of immunology (Baltimore, Md. : 1950), 2008, 181
  http://rdf.ncbi.nlm.nih.gov/pubmed/18713982
• Ping. Wang, et.al., Predictive imaging of chemotherapeutic response in a transgenic mouse model of pancreatic cancer., International journal of cancer, 2016, 139
  http://rdf.ncbi.nlm.nih.gov/pubmed/26996122