increased prostate intraepithelial neoplasia incidence_Pten<tm2.1Ppp>/Pten<+>,Spry1<tm1Jdli>/Spry1<tm1.1Jdli>,Spry2<tm1Mrt>/Spry2<tm1.1Mrt>,Tg(Osr1-cre)4Mrt/0

http://metadb.riken.jp/0009219I129P2OlaHsd129S1Sv129X1SvJFVBNPtentm21PppPtenSpry1tm1JdliSpry1tm11JdliSpry2tm1MrtSpry2tm11MrtTgOsr1cre4Mrt0Spry2tm1MrtPtentm21PppTgOsr1cre4MrtSpry1tm11JdliPtenSpry2tm11MrtSpry1tm1Jdli

increased prostate intraepithelial neoplasia incidence_Pten<tm2.1Ppp>/Pten<+>,Spry1<tm1Jdli>/Spry1<tm1.1Jdli>,Spry2<tm1Mrt>/Spry2<tm1.1Mrt>,Tg(Osr1-cre)4Mrt/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• sprouty homolog 2 (Drosophila)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1345138
• phosphatase and tensin homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:109583
• sprouty homolog 1 (Drosophila)
  http://metadb.riken.jp/db/mgi_rdf/MGI:1345139
• transgene insertion 4, Gail R Martin
  http://metadb.riken.jp/db/mgi_rdf/MGI:3793841

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Pten<tm2.1Ppp>/Pten<+>,Spry1<tm1Jdli>/Spry1<tm1.1Jdli>,Spry2<tm1Mrt>/Spry2<tm1.1Mrt>,Tg(Osr1-cre)4Mrt/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Spry2<tm1Mrt>|Pten<tm2.1Ppp>|Tg(Osr1-cre)4Mrt|Spry1<tm1.1Jdli>|Pten<+>|Spry2<tm1.1Mrt>|Spry1<tm1Jdli>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009219

文献

http://purl.org/net/cito/citesAsAuthority

• Jennifer L. Schutzman, et.al., Sprouty genes function in suppression of prostate tumorigenesis., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/23150596