increased prostate intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Tg(Pbsn-cre)4Prb/0

http://metadb.riken.jp/0009219I129P2OlaHsdC57BL6DBA2FVBNGtROSA26Sortm1CAGBmi1EGFPNkiGtROSA26SorTgPbsncre4Prb0GtROSA26Sortm1CAGBmi1EGFPNkiTgPbsncre4PrbGtROSA26Sor

increased prostate intraepithelial neoplasia incidence_Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Tg(Pbsn-cre)4Prb/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• gene trap ROSA 26, Philippe Soriano
  http://metadb.riken.jp/db/mgi_rdf/MGI:104735
• transgene insertion 4, Pradip Roy-Burman
  http://metadb.riken.jp/db/mgi_rdf/MGI:2388169

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>/Gt(ROSA)26Sor<+>,Tg(Pbsn-cre)4Prb/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Gt(ROSA)26Sor<tm1(CAG-Bmi1,-EGFP)Nki>|Tg(Pbsn-cre)4Prb|Gt(ROSA)26Sor<+>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * FVB/N

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate intraepithelial neoplasia incidence
  http://purl.obolibrary.org/obo/MP_0009219

文献

http://purl.org/net/cito/citesAsAuthority

• Karim. Nacerddine, et.al., Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer., The Journal of clinical investigation, 2012, 122
  http://rdf.ncbi.nlm.nih.gov/pubmed/22505453