increased prostate gland adenocarcinoma incidence_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0

http://metadb.riken.jp/0009220I129S6SvEvTacC57BL6DBA2Tgfbr2tm12HlmTgfbr2tm12HlmTgCol1a2creERTALPP7Cpd0Tgfbr2tm12HlmTgCol1a2creERTALPP7Cpd

increased prostate gland adenocarcinoma incidence_Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• transgene insertion 7, Christopher P Denton
  http://metadb.riken.jp/db/mgi_rdf/MGI:3785759
• transforming growth factor, beta receptor II
  http://metadb.riken.jp/db/mgi_rdf/MGI:98729

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Tgfbr2<tm1.2Hlm>/Tgfbr2<tm1.2Hlm>,Tg(Col1a2-cre/ERT,-ALPP)7Cpd/0

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Tgfbr2<tm1.2Hlm>|Tg(Col1a2-cre/ERT,-ALPP)7Cpd

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S6/SvEvTac * C57BL/6 * DBA/2

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased prostate gland adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009220

文献

http://purl.org/net/cito/citesAsAuthority

• Roger S. Jackson, et.al., Sabutoclax, a Mcl-1 antagonist, inhibits tumorigenesis in transgenic mouse and human xenograft models of prostate cancer., Neoplasia (New York, N.Y.), 2012, 14
  http://rdf.ncbi.nlm.nih.gov/pubmed/22904682