increased adenocarcinoma incidence_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

http://metadb.riken.jp/0009308I129S1Sv129X1SvJCdk4tm21BbdCdk4tm21BbdKrastm1BbdKrastm2BbdPolr2atm1creERT2BbdPolr2atm1creERT2BbdCdk4tm21BbdKrastm1BbdPolr2atm1creERT2BbdKrastm2Bbd

increased adenocarcinoma incidence_Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• cyclin-dependent kinase 4
  http://metadb.riken.jp/db/mgi_rdf/MGI:88357
• polymerase (RNA) II (DNA directed) polypeptide A
  http://metadb.riken.jp/db/mgi_rdf/MGI:98086

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Cdk4<tm2.1Bbd>/Cdk4<tm2.1Bbd>,Kras<tm1Bbd>/Kras<tm2Bbd>,Polr2a<tm1(cre/ERT2)Bbd>/Polr2a<tm1(cre/ERT2)Bbd>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Cdk4<tm2.1Bbd>|Kras<tm1Bbd>|Polr2a<tm1(cre/ERT2)Bbd>|Kras<tm2Bbd>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S1/Sv * 129X1/SvJ

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009308

文献

http://purl.org/net/cito/citesAsAuthority

• Marta. Puyol, et.al., A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma., Cancer cell, 2010, 18
  http://rdf.ncbi.nlm.nih.gov/pubmed/20609353