increased adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>,Trp53<tm5Tyj>/Trp53<+>

http://metadb.riken.jp/0009308I129S4SvJaeSor129S6SvEvTacC57BL6Krastm4TyjKrasScgb1a1tm1creERTBlhScgb1a1Trp53tm5TyjTrp53Scgb1a1tm1creERTBlhScgb1a1Trp53KrasTrp53tm5TyjKrastm4Tyj

increased adenocarcinoma incidence_Kras<tm4Tyj>/Kras<+>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>,Trp53<tm5Tyj>/Trp53<+>

表現型アノテーション

MGI marker

http://metadb.riken.jp/db/mgi_rdf/variant_of

• Kirsten rat sarcoma viral oncogene homolog
  http://metadb.riken.jp/db/mgi_rdf/MGI:96680
• secretoglobin, family 1A, member 1 (uteroglobin)
  http://metadb.riken.jp/db/mgi_rdf/MGI:98919
• transformation related protein 53
  http://metadb.riken.jp/db/mgi_rdf/MGI:98834

遺伝子型

http://metadb.riken.jp/db/mgi_rdf/allele_composition

• Kras<tm4Tyj>/Kras<+>,Scgb1a1<tm1(cre/ERT)Blh>/Scgb1a1<+>,Trp53<tm5Tyj>/Trp53<+>

アレルシンボル

http://metadb.riken.jp/db/mgi_rdf/allele_symbol

• Scgb1a1<tm1(cre/ERT)Blh>|Scgb1a1<+>|Trp53<+>|Kras<+>|Trp53<tm5Tyj>|Kras<tm4Tyj>

遺伝的背景

http://metadb.riken.jp/db/mgi_rdf/genetic_background

• involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

MP annotation

http://metadb.riken.jp/db/bioresource_schema/brs_indicatesPhenotype

• increased adenocarcinoma incidence
  http://purl.obolibrary.org/obo/MP_0009308

文献

http://purl.org/net/cito/citesAsAuthority

• Xia. Xu, et.al., Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma., Proceedings of the National Academy of Sciences of the United States of America, 2012, 109
  http://rdf.ncbi.nlm.nih.gov/pubmed/22411819